This video is a brief demonstration of some of the research ongoing in the university of Sheffield’s dentistry department.
Titanium implants are used to permanently replace teeth. During the surgery to implant titanium screws, wounding of the soft and hard tissue is inevitable.
We are hoping to speed the recovery of the wound healing by using the bone fragments removed from the patient during the surgery. We are manufacturing electrospun membranes containing microfeatures to act as stem cell reservoirs.
When the bone fragments are placed within these microfeatures the mesenchymal stem cells from within the bone migrate into the electrospun membrane. The membrane will then be placed into the wound bed. From here the stem cells will proliferate and differentiate into the cells required to promote rapid wound healing.
The membrane will degrade slowly overtime preventing the need of additional surgery to remove it.
Artificial niches for enhanced dental healing